where R1 - unsaturated heterocyclic group with 5 ring atoms one of that is nitrogen and possibly substituted by one of carbon atom with OH-group or C1-20-alkanoyl- -hydroxy-group and possibly substituted by nitrogen atom with C1-6-alkyl; R2a,R2b,R2c - H, methyl, methoxy-group, F, Cl, Br; R3a,R3b,R3c,R3d - H, C1-6-alkoxy-group or halogen atom, and their pharmaceutically acceptable salts and esters. Compounds of the formula (I) are antagonists of serotonin-2-receptors and show capability to inhibit squalene synthase activity. EFFECT: valuable biochemical and pharmacological properties of compounds. 18 cl, 4 tbl, 20 ex"/>
DERIVATIVES OF DIARYLALKANES CONTAINING ALICYCLIC GROUP AND ELICITING ANTAGONISM WITH RESPECT TO SEROTONIN-2-RECEPTORS AND/OR INHIBITORY ACTIVITY WITH RESPECT TO SQUALENE SYNTHASE, COMPOSITION FOR TREATMENT AND PROPHYLAXIS OF CARDIOVASCULAR DISEASES
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DERIVATIVES OF DIARYLALKANES CONTAINING ALICYCLIC GROUP AND ELICITING ANTAGONISM WITH RESPECT TO SEROTONIN-2-RECEPTORS AND/OR INHIBITORY ACTIVITY WITH RESPECT TO SQUALENE SYNTHASE, COMPOSITION FOR TREATMENT AND PROPHYLAXIS OF CARDIOVASCULAR DISEASES
DERIVATIVES OF DIARYLALKANES CONTAINING ALICYCLIC GROUP AND ELICITING ANTAGONISM WITH RESPECT TO SEROTONIN-2-RECEPTORS AND/OR INHIBITORY ACTIVITY WITH RESPECT TO SQUALENE SYNTHASE, COMPOSITION FOR TREATMENT AND PROPHYLAXIS OF CARDIOVASCULAR DISEASES
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of diarylalkanes of the formula (I) where R1 - unsaturated heterocyclic group with 5 ring atoms one of that is nitrogen and possibly substituted by one of carbon atom with OH-group or C1-20-alkanoyl- -hydroxy-group and possibly substituted by nitrogen atom with C1-6-alkyl; R2a,R2b,R2c - H, methyl, methoxy-group, F, Cl, Br; R3a,R3b,R3c,R3d - H, C1-6-alkoxy-group or halogen atom, and their pharmaceutically acceptable salts and esters. Compounds of the formula (I) are antagonists of serotonin-2-receptors and show capability to inhibit squalene synthase activity. EFFECT: valuable biochemical and pharmacological properties of compounds. 18 cl, 4 tbl, 20 ex
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机译：领域：有机化学，药学。物质：本发明涉及式（I）的二芳基烷烃的衍生物。<图像文件=“ 00000002.GIF” he =“ 37” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 53” />其中R 具有5个环原子的1 -不饱和杂环基团，其中一个为氮原子，并可能被具有OH-或C 1-20 -烷酰基-羟基的碳原子之一取代，并且可能被氮原子取代为C 1-6 -烷基; R 2a ，R 2b ，R 2c -H，甲基，甲氧基，F，Cl，Br; R 3a ，R 3b ，R 3c ，R 3d -H，C 1-6 < -Sub-烷氧基或卤素原子，及其药学上可接受的盐和酯。式（I）的化合物是5-羟色胺-2-受体的拮抗剂，并显示出抑制鲨烯合酶活性的能力。效果：化合物的重要生化和药理特性。 18 cl，4 tbl，20前
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