New beta, gamma-fused lactone glutamate receptor modulators for treating cerebral ischemia, cranial or brain trauma, pain or CNS-mediated spasms

摘要

beta , psi -Fused lactones of formula (I) and their salts are new: R1+R2 = a group of formula (i)-(vi) optionally substituted by 1-3 OH groups: R3 = H, 1-6C alkyl or 2-6C alkenyl and R4 = CH2R5, or R3 = 2-6C alkenyl and R4 = H; R5 = 6-10C aryl or 2- or 3-benzothienyl, optionally substituted by 1 or more halogen and/or 1-6C alkyl.