New nucleic acid sequences expressed in uterine myoma, and derived polypeptides, for treatment of uterine carcinoma and identification of therapeutic agents

摘要

Polypeptide sequences (I) and their fragments are new and comprise 19 open reading frame sequences given in the specification, that are highly expressed in uterine myoma. Independent claims are also included for the following: (1) 31 specific nucleic acids (II) encoding (I), comprising amino acid sequences fully defined in the specification; (2) bacterial or phage artificial chromosomes and cosmid clones containing functional genes, or the chromosome region containing them, corresponding to (II) for use as gene transfer vehicles; (3) antisense sequences to (II); (4) an expression cassette (III) comprising (II), or their fragments, plus control and regulatory sequences; (5) DNA fragments (IV) containing a gene isolated using (II); (6) host cells (V) containing (II) as a heterologous component; (7) recombinant production of (I), or their fragments, by culturing (V); (8) an antibody (VI) directed against (I), or its fragments, encoded by (II); and (9) 20 partial polypeptide sequences, all reproduced, and sequences having at least 80% homology with them.