7-thia guanosine derivatives with antiviral, antitumoral, antimetastatic and immunostimulating effects

摘要

Use of a compound of the structure: CHEM wherein R4, R5, R6 and R7 individually are H, OH or C1-C18 O-acyl and R3 is H, C1-C18 acyl or CHEM or R5 and R7 are H or OH, R6 is H and together R3 and R4 are CHEM and X is =O or =S; Y is -OH, -SH, -NH2 or halogen; and Z is H, -NH2, -OH or halogen; wherein halogen is Cl or Br; or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating a virus in a mammal.