首页>
外国专利>
Molecules with antibody binding sites, catalyze the hydrolysis reactions
Molecules with antibody binding sites, catalyze the hydrolysis reactions
展开▼
机译:具有抗体结合位点的分子,催化水解反应
展开▼
页面导航
摘要
著录项
相似文献
摘要
An antibody molecule or molecule containing antibody combining site portions (catalytic molecule) that catalytically hydrolyzes a preselected carboxylic acid amide or ester bond of a reactant ligand, methods of making and using the catalytic molecule, and cells that produce those molecules are disclosed. The catalytic molecules bind to a reactant ligand containing the bond to be hydrolyzed and also to a haptenic ligand. The haptenic ligand is structurally analogous to the reactant ligand and contains a tetrahedral carbon atom that is bonded to a hydroxyl group and to a saturated carbon atom at a position in the haptenic ligand that corresponds to position of the carbonyl group and its bonded heteroatom of the reactant ligand. The haptenic ligand also contains a group that bears an ionic charge in aqueous solution at physiological pH values that is not present at a corresponding position of the reactant ligand. The ionic charge-bearing group is located in the hapten within 7 ANGSTROM ngstroms of the tetrahedral carbon atom.
展开▼