首页>
外国专利>
pyrido pyridazinon and pyridazinthionverbindungen with pde iv inhibierender effect
pyrido pyridazinon and pyridazinthionverbindungen with pde iv inhibierender effect
展开▼
机译:吡啶并吡嗪酮和哒嗪硫磷并具有pde iv抑制剂作用
展开▼
页面导航
摘要
著录项
相似文献
摘要
Benzo or pyridopyridazinones and pyridazinthiones of formula (I) wherein: X and Y are nitrogen or carbon, provided that at least one is carbon, and Z is oxygen or sulfur; R1 is hydrogen, lower alkyl, aryl, heteroaryl, or heterocycle lower alkylene; R2, R3, R4, R5 and R6 are independently selected from hydrogen, lower alkyl, halo, carboxy, alkoxycarbonyl, carbamoyl, acyl, acyl halide, thiomethyl, trifluoromethyl, cyano or nitro; or a pharmaceutically acceptable ester, ether or salt thereof, have been found to be useful as an anti-inflammatory, antiasthmatic, immunosuppressive, anti-allograft rejection, anti-graft-vs-host rejection, autoimmune disease or analgetic agent(s).
展开▼
机译:式(I)的苯甲酰基或吡啶并吡啶并二酮和哒嗪硫酮,其中:X和Y为氮或碳,条件是至少一个为碳,Z为氧或硫; R 1为氢,低级烷基,芳基,杂芳基或杂环的低级亚烷基; R 2,R 3,R 4,R 5和R 6独立地选自氢,低级烷基,卤素,羧基,烷氧基羰基,氨基甲酰基,酰基,酰基卤,硫代甲基,三氟甲基,氰基或硝基;或其药学上可接受的酯,醚或盐已发现可用作抗炎,抗哮喘,免疫抑制,抗同种异体移植排斥,抗移植物与宿主排斥,自身免疫性疾病或镇痛药。
展开▼