SUCCINAMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS GELATINASE AND COLLAGENASE INHIBITORS

摘要

PCT No. PCT/GB94/01697 Sec. 371 Date Apr. 4, 1996 Sec. 102(e) Date Apr. 4, 1996 PCT Filed Aug. 2, 1994 PCT Pub. No. WO95/04033 PCT Pub. Date Feb. 9, 1995Compounds of formula (1) are described, wherein R1 represents (a), where R3 is a hydrogen or halogen atom or a methyl, trifluoromethyl or methoxy group; R2 represents a hydrogen atom or a methyl group; and the salts, solvates, hydrates and prodrugs thereof. The compounds are potent and selective orally active inhibitors of the metalloproteinase gelatinase with a long duration of action, and in particular inhibit angiogenesis in vivo. They can therefore be expected to be of use in the prophylaxis or treatment of angiogenesis dependent disorders such as solid tumours and arthritic diseases.