PROCESS FOR THE PREPARATION OF VESICULAR-LIKE NANOCAPSULES FOR USE IN PARTICULAR AS COLLOIDAL VECTORS OF PHARMACEUTICAL ACTIVE PRINCIPLES OR THE LIKE

摘要

The invention concerns the preparation of nanoparticles for encapsulating active principles, and more precisely a method for obtaining vesicular nanoparticles dispersible in aqueous phase in colloidal form, which are non-toxic, biologically compatible, stable in colloidal suspension, protecting well the active principle and simply and inexpensively obtainable. The method consists in using two non-oily phases S1 (ethyl acetate) and S2 (water), non-miscible with each other and a third oily phase S3 (mygliol); in producing an oil-in-water emulsion whereof the dispersed phase comprises S3, S1, or a polymer PE dissolved in S1 and designed to form the nanocapsule envelope and optionally a dissolved active principle PA (S1 being brought by a solution saturated with S2 in S1) and whereof the continuous phase is S2 = non-solvent of PE; and in extracting from the dispersed phase, ensuring that the conditions of the continuous phase are such that S1 is miscible in S2, thereby obtaining a stable colloidal solution of nanocapsules with diameter of the order of 300 nanometers.