首页> 外国专利> PEPTIDE LIGAND HAVING SPECIFIC AFFINITY TO PROTEIN P24 OF RETROVIRUS HIV-1

PEPTIDE LIGAND HAVING SPECIFIC AFFINITY TO PROTEIN P24 OF RETROVIRUS HIV-1

机译:具有对逆转录病毒HIV-1蛋白P24的特异性亲和力的肽配体

摘要

The invention concerns a peptide ligand having specific affinity for the HIV1 retrovirus p24 protein, comprising at least a peptide strand corresponding to an antibody light chain and/or heavy chain N-terminal. The invention is characterised in that the light chain comprises a sequence of amino acids determining three regions said to hypervariable L1, L2 and L3, respectively positioned from 70 to 99, from 145 to 165, from 262 to 285, as per the amino acid sequence described by the sequence SEQ ID No 1, and the heavy chain comprises an amino acid sequence said to be hypervariable H1, H2 and H3, respectively positioned from 76 to 105, from 155 to 195, from 295 to 327, as per the amino acid sequence described by the sequence SEQ ID No 2.
机译:本发明涉及对HIV1逆转录病毒p24蛋白具有特异性亲和力的肽配体,其至少包含对应于抗体轻链和/或重链N-末端的肽链。本发明的特征在于,轻链包含一个氨基酸序列,该氨基酸序列确定了根据氨基酸序列分别确定为高变L1,L2和L3的三个区域,分别位于70至99、145至165、262至285 SEQ ID No.1所示的重链,并且重链包含据称是高变的H1,H2和H3的氨基酸序列,分别根据氨基酸位于76至105、155至195、295至327序列SEQ ID No 2所描述的序列。

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