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Medicaments for the treatment of primary headache disorders and drug-induced headaches
Medicaments for the treatment of primary headache disorders and drug-induced headaches
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机译:用于治疗原发性头痛和药物性头痛的药物
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摘要
The present invention provides for the treatment of primary headache disorders, particularly migraine, using antagonists of the EP4 receptor for prostaglandin E2. Particular EP4 receptor antagonists include azole compounds of formula (I): wherein R1 is a group such as lower alkyl substituted with carboxy; R2 is hydrogen or lower alkyl, R3 and R4 are aryl optionally substituted with halogen, Q is in which -A1- is a single bond or lower alkylene, is a cyclo group, -A3- is a single bond or lower alkylene, and X is O, NH or S; or a salt or its solvate thereof.
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机译:本发明提供了使用前列腺素E2的EP4受体的拮抗剂来治疗原发性头痛疾病,特别是偏头痛。特定的EP4受体拮抗剂包括式(I)的唑化合物:其中R1是诸如被羧基取代的低级烷基的基团; R 2是氢或低级烷基,R 3和R 4是任选地被卤素取代的芳基,Q其中-A 1-是单键或低级亚烷基,是环基,-A 3-是单键或低级亚烷基,并且X是O,NH或S;或其盐或其溶剂化物。
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