A spinal-epidural administration set includes a spinal needle having a hub and an increased diameter zone extending axially from the hub toward a distal tip. Equidistantly spaced teeth project radially from the zone. The spinal needle is inserted through a hub of an epidural needle whose distal end is positioned within an epidural space. The epidural needle hub includes a throat having a keyway formed of pair of opposed flanges spaced apart a distance sufficient to provide channels for the teeth to pass into a lumen of the epidural needle. When the tip of the spinal needle penetrates the dural membrane, the spinal needle is rotated to engage axially spaced adjacent teeth between the flanges, axially locking the spinal needle. A syringe may then be attached to the spinal needle hub. In order to provide additional extension of the spinal needle through the dural membrane without advancing the epidural needle in the epidural space, the epidural needle hub includes a removable barrel.
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