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Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells
Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells
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机译:黄嘌呤用于鉴定可激活动物细胞中氯传导的CFTR结合化合物
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摘要
The present invention provides novel compounds and pharmaceutical compositions comprising such compounds useful for treating cystic fibrosis cells, wherein such compounds have the formula ##STR1## wherein (a) R.sub.1 and R.sub.3 are methyl, R.sub.7 is ethyl or cyclopropylmethyl, and R.sub.8 is cyclohexyl; (b) R.sub.1 and R.sub.3 are allyl, R.sub.7 is hydrogen and R.sub.8 is cyclohexyl, cyclohexylmethyl, or cycloheptyl; (c) R.sub.1 is allyl and R.sub.3 is methyl, R.sub.7 is hydrogen, and R.sub.8 is cyclohexyl; or (d) R.sub.1 is methyl, R.sub.3 is allyl, R.sub.7 is cyclopropylmethyl or ethyl, and R.sub.8 is cyclohexyl.
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