Oligosaccharides reactive with hyaluronan-binding protein and their methods of use

摘要

Hyaluronan-binding protein (HABP) is expressed on the cell surface during tumor cell and endothelial cell migration and during capillary- like tubule formation. Monoclonal antibodies and hyaluronan oligosaccharides are described which specifically recognize HABP and can be used to (1) inhibit tumor growth by preventing tumor vascularization, (2) inhibit tumor cell migration and (3) image tumors.