Tetracycline repressor-mediated binary regulation system for control of gene expression in transgenic mice

摘要

The present invention relates to a tetracycline repressor- mediated binary regulation system for the control of gene expression in transgenic mice. It is based, at least in part, on the discovery that, in a transgenic mouse that carries a first transgene under the control of a modified promoter comprising a tetR operator sequence and a second transgene encoding the tetR protein, expression of the first transgene may be efficiently induced by administering tetracycline to the mouse.