Factor VII fragment 82-128 and its use in blood-clotting disorders

摘要

The present invention relates to peptide of the amino acid sequence of formula (I):PP 82 85 90 PP Glu Thr His Lys Asp Asp Gln Leu Ile PP 95 100 P PCys Val Asn Glu Asn Gly Gly Cys Glu Gln PP 105 110 P PTyr Cys Ser Asp His Thr Gly Thr Lys Arg P P 115 120 PPSer Cys Arg Cys His Glu Gly Tyr Ser Leu P P 125 128 PPLeu Ala Asp Gly Val Ser Cys Thr (SEQ ID NO. 1) PPPPand functional equivalents thereof in which amino acids in the above stated sequence are modified or absent and wherein at least one of the cysteine residues may be blocked or replaced and wherein any cysteine residues which remain unblocked or unreplaced may be present in a disulphide bonded state. The invention also includes slats and derivatives of said peptides. The peptides and their salts and derivatives are useful in the treatment of blood clotting disorders.