Efficient method for the synthesis of N-cyclic maleamic acids and N- cyclic maleimides

摘要

Provided are methods for the synthesis of N-cyclic maleamic acids and N-cyclic maleimide derivatives, as well as N-cyclic maleamic acids and N- cyclic maleimides synthesized thereby. The method for synthesis of an N- cyclic maleamic acid involves reacting an amino group- containing N- cyclic compound with maleic anhydride in acetic acid to obtain an N- cyclic maleamic acid. An N-cyclic maleimide can be formed by adding hexamethyldisilazane to an N-cyclic maleamic acid prepared according to the above-described method, thereby cyclizing a maleamic acid site of the N-cyclic maleamic acid. The described methods allow for the products to be obtained at high yields.