Method of identifying inhibitors of glutathione S-transferase (GST) gene expression

摘要

Complementary DNA and genomic clones for three variants of GST- are disclosed. It is demonstrated that certain of these variants are overexpressed in gliomas, thereby indicating an involvement with that form of cancer. This permits the detection and treatment of certain classes of tumors using new compositions such as GST- genes, oligonucleotides, peptides and antibodies.