Manufacturing method of isolating atracurium besylate

摘要

I to provide a process for the production of atracurium besylate, which substantially reduce the impurity concentration (57) [summary] the final product, to avoid the repeated use of ether. According to the method, N, N'-4,10- dioxa-3,11-dioxo-tri-decylene 1,13-bis - solvent insoluble base and a catalytic amount of benzenesulfonic acid and methyl (Compound 1) tetrahydropyran Papa Berg Ng to form a reaction mixture in a mixture in the middle, to maintain the reaction mixture for a sufficient time to atracurium besylate formation. Then, to remove insoluble base, if the reaction mixture was filtered, and precipitated the atracurium besylate.