Piperidino derivatives that stimulate growth hormone release.

摘要

A pharmaceutically useful compound of formula (I) wherein R1 is hydrogen and X is a group of formula (II) in which R3 is esterified carboxy and R4 is ar(lower) alkyl; R3 is cyano and R4 is aryl; R3 is hydrogen and R4 is 2-oxo-1-benzimidazolinyl; or R3 and R4 are linked together to form formula (III) in which R5 is acyl, formula (a) is piperidino, and Y is lower alkanetriyl; or R1 is a group of formula (IV) in which R3, R4 and formula (a) are each as defined above and X is bond, R2 is 3-azetidinyl, 4-piperidyl or a group of the formula: -Z-NHR6 in which R6 is hydrogen or amino protective group, and Z is lower alkylene or cyclo (lower) alkylene, and A is -(CH2)n-, in which n is 3, 4 or 5, or -CH=CH-(CH2)m-, in which m is 1, 2 or 3, and salts thereof. The compound or a salt thereof of the present invention has excellent promotion activity of growth hormone release for animals and human bodies.