Improved method for producing biodegradable polymer microspheres using solvent extraction and method for producing microspheres for treating local inflammation using the same

摘要

PCT No. PCT/KR97/00055 Sec. 371 Date Aug. 2, 1999 Sec. 102(e) Date Aug. 2, 1999 PCT Filed Apr. 1, 1997 PCT Pub. No. WO97/36949 PCT Pub. Date Oct. 9, 1997A preparation method for biodegradable polymeric microspheres using a solvent extraction method for biodegradable polymeric microspheres for treating a local inflammation disease using the same which are capable of effectively curing ozena such as sinusitis and a middle ear infection. Since a non-solvent of polymer is added into an outer aqueous phase in advance, the solidification of the polymer is implemented in a short time which, in turn, improves encapsulation of the therapeutic agent used.