Use of raloxifene and related compounds for the manufacture of a medicament for lowering plasma levels of lipoprotein (a)

摘要

A method of lowering plasma levels of Lp(a) or inhibiting the generation of apo(a) in a human by administering an effective amount of a compound of the formula: IMAGE (I) wherein n is 0, 1 or 2: R1 is hydrogen, alkyl, alkanoyl, cycloalkanoyl, (alkoxy)alkanoyl, aroyl, aryloxycarbonyl; R2 is hydrogen, hydroxy, halo, alkoxy, alkanoyloxy, cycloalkanoyloxy, (alkoxy)alkanoyloxy, aroyloxy, aryloxycarbonyloxy; R3 is pyrrolidinyl or piperidinyl; or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient, is disclosed.