首页> 外国专利> PROMOTER FOR CEREBRAL BLOOD VESSEL REPRODUCTION/ RESTRUCTURING AND INHIBITOR AGAINST SECONDARY NERVE TISSUE SECONDARY DENATURATION COMPRISING GINSENOSIDE Rb1

PROMOTER FOR CEREBRAL BLOOD VESSEL REPRODUCTION/ RESTRUCTURING AND INHIBITOR AGAINST SECONDARY NERVE TISSUE SECONDARY DENATURATION COMPRISING GINSENOSIDE Rb1

机译:人参皂甙Rb1对次神经组织二次变性的脑血管再生/重组和抑制剂的促进剂

摘要

PROBLEM TO BE SOLVED: To obtain the subject composition capable of protecting a damaged brain for a long period of time by showing excellent promoting action on cerebral blood vessel reproduction and restructuring by intravenous administration after apoplexy and inhibiting secondary denaturation of nerve tissue by making the composition include ginsenoside Rb1. SOLUTION: This parenteral administration preparation contains ginsenoside Rb1 (compound of the formula) or its metabolic product. Preferably the parenteral preparation contains the active ingredient in a low concentration. To be more concrete, the extracellular fluid concentration is preferably =1 ng/ml, more preferably =1 pg/ml, further preferably =100 fg/ml. The daily dose of the medicine composition for human apoplexy patient or spinal cord injury patient is =0.1 mg, preferably =1 mg, more preferably =10 mg and its upper limit is =1 g, preferably =0.1 g.
机译:要解决的问题:通过中风后静脉内给药对脑血管的再生和重构显示出优异的促进作用,并通过制得该组合物抑制神经组织的二次变性,从而获得能够长期保护受损脑的主题组合物。包括人参皂甙Rb1。溶液:这种肠胃外给药制剂含有人参皂甙Rb1(该配方的化合物)或其代谢产物。优选地,肠胃外制剂包含低浓度的活性成分。更具体而言,细胞外液浓度优选≤1ng/ ml,更优选≤1pg/ ml,进一步优选≤100fg/ ml。用于人中风患者或脊髓损伤患者的药物组合物的日剂量为≥0.1mg,优选≥1mg,更优选≥10mg,其上限≤1g,优选≤0.1g。

著录项

  • 公开/公告号JP2000302798A

    专利类型

  • 公开/公告日2000-10-31

    原文格式PDF

  • 申请/专利权人 JAPAN SCIENCE & TECHNOLOGY CORP;

    申请/专利号JP19990340850

  • 发明设计人 SAKANAKA MASAHIRO;TANAKA JUNYA;SATO KOJI;

    申请日1999-11-30

  • 分类号C07J17/00;A61K9/08;A61K31/704;A61P9/00;A61P25/00;

  • 国家 JP

  • 入库时间 2022-08-22 02:01:25

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