SEVEN-PASS TRANSMEMBRANE RECEPTOR PROTEIN ERG 5

摘要

PROBLEM TO BE SOLVED: To obtain a new seven-pass transmembrane receptor protein ERG 5 which is composed of a seven-pass transmembrane through type receptor protein EGR 5 containing the sequence substantially identical to a specific amino acid sequence and is useful for the detection of tumor cells or the development of medicines controlling the multiplication and the function of tumor cell or the like. ;SOLUTION: This receptor is a new seven-pass transmembrane receptor protein ERG 5 (salt) containing the amino acid sequence substantially identical to the amino acid sequence represented by the formula and is useful for the detection of tumor cells or the development of medicines controlling the multiplication and the function of various cells containing tumor cells. This protein is obtained by screening a cDNA library arising from mouse lung by means of using cDNA of ERG family obtained from experimental allergic encephalomyelitis critical autoreactive T cell 4R312 arising from mouse as a probe, integrating a gene coding the resultant ERG 5 into a vector to product the expression system and then introducing this into host cell to express.;COPYRIGHT: (C)2000,JPO