SBHUNC50 POLYPEPTIDE AND SBHUNC50 POLYNUCLEOTIDE

摘要

PROBLEM TO BE SOLVED: To obtain a new SBHUNC50 polypeptide containing an amino acid sequence having high identity with the whole length of a specific amino acid sequence, and useful in e.g. the treatment, diagnoses of epilepsy, convulsion, megrim, neurodegeneration, psychiatric disorders, etc. SOLUTION: This isolated new polypeptide contains an amino acid sequence having at least 97% identity with the whole length of an amino acid sequence of the formula, being useful for e.g. the treatment and diagnostic assay of dysfunctions or diseases including epilepsy, convulsion, megrim, neurodegeneration, developmental disorders and psychiatric disorders. This new polypeptide is obtained by the following procedure: a polynucleotide obtained, using EST analysis, by the standard cloning and screening, from a cDNA library derived from mRNA such as of human neonatal brain, fetal liver/spleen or T-lymphocytes, is transferred into an expression system followed by expression of the polynucleotide in host cells.