首页> 外国专利> To improve the permeation process in the skin of a pharmacologically Active Compound, applied topically,In which otherwise has unavelocidad Low Skin Penetration; Sectional Mounting devices and useful in this process.

To improve the permeation process in the skin of a pharmacologically Active Compound, applied topically,In which otherwise has unavelocidad Low Skin Penetration; Sectional Mounting devices and useful in this process.

机译:为了改善局部应用的药理活性化合物在皮肤中的渗透过程,否则该化合物没有明显的低皮肤渗透性;分段安装设备,在此过程中很有用。

摘要

Processes and means, such as a distributed device or a distribution device or including a support layer (2), drug preparation (4),Preparation of improved permeable equipment (6)Pressure (8) diffusion film (10), adhesive (12) and release coating (14) for diaphragm separation,1. In order to improve the epidermis, transdermal and skin permeability of a drug active agent, it can be applied on the basis of experiments (for example, ACO pills or steroids, aspirin, phenylbutane, enzyme inhibitors, etc.);In the absence of water permeable improvers, the skin penetration rate is very low, unstable, unstable and insoluble, and Uranus has a long storage time, with special water permeable improvers (such as alcohol, fatty alcohol and ester). The first experiment consisted of a drug, a salt, chemical analysis or chemical formulation, in an acceptable dermatology vehicle and a second ingredient, which contained an acceptable vehicle for penetration improvement. Physically, composition is separated until a surface of the body or face is applied, and theoretically applicable,Whether at the same time or continuously for a short period of time, one in the other, mixing or combining to form the final active ingredient in the foot L. allow the amount of therapeutic drugs supplied to the skin and the circulation of the system, Through the use of a synthetic penetration enhancer at the point of use.
机译:诸如分布式设备或分布式设备或包括支撑层(2),药物制剂(4),改进的可渗透设备的制备(6)压力(8)扩散膜(10),粘合剂(12)的过程和装置并释放用于隔膜分离的涂层(14)1。为了改善药物活性剂的表皮,透皮和皮肤通透性,可以在实验的基础上应用(例如ACO丸或类固醇,阿司匹林,苯基丁烷,酶抑制剂等);透水性改良剂,皮肤渗透率非常低,不稳定,不稳定和不溶,并且天王星具有较长的储存时间,并带有特殊的透水​​性改良剂(例如酒精,脂肪醇和酯)。第一个实验由药物,盐,化学分析或化学制剂组成,在可接受的皮肤病学媒介物中,第二个成分包含在改善渗透性方面可接受的媒介物。在物理上,将组合物分开直到施用到身体或面部的表面为止,并且从理论上讲是适用的,无论是在同一时间还是在短时间内连续进行,彼此混合或混合形成最终的活性成分。足L.通过在使用时使用合成的渗透促进剂,允许向皮肤供应的治疗药物的量和系统的循环。

著录项

  • 公开/公告号AR009428A1

    专利类型

  • 公开/公告日2000-04-12

    原文格式PDF

  • 申请/专利权人 BRISTOL-MYERS SQUIBB COMPANY;

    申请/专利号AR1997P105339

  • 发明设计人

    申请日1997-11-14

  • 分类号A61K47/00;A61K9/70;

  • 国家 AR

  • 入库时间 2022-08-22 01:57:34

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