首页> 外国专利> A compound derived from (1h indole - 3 - yl) - 5 - (2H pyrrole - 2 - ylidene) methyl - 1H pyrrole, use a procedure to produce,Ycomposiciones Pharmaceutical Products comprising Said Compound, a compound useful as an intermediate for preparing Said compound and Preparation

A compound derived from (1h indole - 3 - yl) - 5 - (2H pyrrole - 2 - ylidene) methyl - 1H pyrrole, use a procedure to produce,Ycomposiciones Pharmaceutical Products comprising Said Compound, a compound useful as an intermediate for preparing Said compound and Preparation

机译:衍生自(1h吲哚-3-yl)-5-[(2H吡咯-2-亚丙基)甲基] -1H吡咯的化合物,使用以下方法生产包括上述化合物的化合物,该化合物为可作为中间体的中间体制备所述化合物及制备方法

摘要

A compound that is a Derivative of (1h indole - 3 - yl) - 5 - [(2H pyrrole - 2 - ylidene) methyl] - 1H pyrrole of the formula (i), where each of R1, R2, R3 and R4, which may be the same or different, representIndependently, C1 - C6 Hydrogen, alkyl, halogen, Nitro, cyano, Hydroxy, alkoxy c6insustituido C1 - replaced by alkyl or phenyl, C1 - C6 - nrarb carbonyloxy, where each of Ra and RB areIndependently Hydrogen or alkyl of C1 - C6 C1 - C6 alkyl, alkoxy carbonylamino, carboxy, C1 - C6 carbonyl), aralquil carbamoilo, arilcarbamoilo, or - conrcrd where each RC and Rd areAn Independent, hydrogen or alkyl or C1 - C6, RC and Rd, taken in conjunction with the nitrogen Atom to which they are linked.Unanillo morpholino or form of piperidino; R5 represents Halogen, Hydroxy or alkoxy - or C1 to C11 insustituido substituted phenyl; and R6 represents Hydrogen, alcanoiloc2 - C20, alquenoilo C3 - C20PHENYL alkyl C1 - C2 - alquenilo C20 and C20, where alcanoilo alquenoilo, alkyl groups, and alquenilo insustituidoso are replaced by between 1 and 3 substituents are selected.Independently, c1-c6 alkoxy, halogen, Hydroxy, carboxy aryl, ariloxi, ciano, (alcoxic1 - carbonyl (C6), alquenilo C3 - C4) carbamoilo, aralquil carbamoilo,Arilcarbamoilo and conrcrd where RC and Rd are as lasdefiniera before; or a pharmaceutically acceptable Salt thereof.It is useful as an immunomodulating Agent. To carry out the treatment of Adult t-cell Leukemia Lymphoma.Use a procedure to produce, products and Pharmaceutical compositions that comprise this,A compound useful as an intermediate for preparing this compound and a combination Preparation comprising an agent
机译:为式(i)的(1h吲哚-3-yl)-5-[(2H吡咯-2-亚叉基)甲基]-1H吡咯的衍生物的化合物,其中R1,R2,R3和R4它们可以相同或不同,分别代表C1-C6氢,烷基,卤素,硝基,氰基,羟基,烷氧基c6-取代成C1-取代成C1-C6-nrarb羰氧基的C1-取代基,其中Ra和RB分别为氢或C1-C6 C1-C6烷基,烷氧基羰基氨基,羧基,C1-C6羰基的烷基),芳基氨基甲酰基,芳基氨基甲酰基或-其中每个RC和Rd是一个独立的氢或烷基或C1-C6,RC和Rd,与它们相连的氮原子一起服用。吗啉吗啉代或哌啶子基形式; R5代表卤素,羟基或烷氧基-或C1至C11取代基取代的苯基; R 6代表氢,alcanoiloc2-C20,alquenoilo C3-C20苯基烷基C1-C2-alquenilo C20和C20,其中Alcanoilo alquenoilo,烷基和Alquenilo insustituidoso被1-3个取代基取代。独立地选择c1-c6烷氧基,卤素,羟基,羧基芳基,芳基,Ciano((含氧的1-羰基(C6),alquenilo C3-C4)),carbamoilo,alralquil carbamoilo,Arilcarbamoilo和conrcrd,其中RC和Rd与之前的lasdefiniera相同;或其药学上可接受的盐。它可用作免疫调节剂。进行成人t细胞白血病淋巴瘤的治疗。使用一种程序生产包含此药物的化合物和药物组合物,用作制备该化合物的中间体的化合物及其组合制剂

著录项

  • 公开/公告号AR011964A1

    专利类型

  • 公开/公告日2000-09-13

    原文格式PDF

  • 申请/专利权人 PHARMACIA & UPJOHN S.P.A.;

    申请/专利号AR1998P101075

  • 发明设计人

    申请日1998-03-11

  • 分类号C07D403/04;C07D403/10;C07F5/02;A61K31/40;

  • 国家 AR

  • 入库时间 2022-08-22 01:57:31

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