Derivatives of quinolein - 2 (1H) - one and dihidroquinolein - 2 (1H) - One, its preparation and its application in Therapeutics.

摘要

Formula compound (I), in which the dial line can be an additional link, G represents (II) at 3 or 4, M = 2-4, Z represents a denitorogeno atom or a group of - CH -,R1 and R2 each independently represent one another, a hydrogen or halogen atom, an amino group, hydroxy, nitro, cyano, (C1-C6) alkyl, (C1-C6) alkoxy, trifluoromethyl, trifluoromethoxy, -COOH, - COOR4, -CONH2, -CONHR4, -CONR4R5, -SR4, -SO2R4, -NHCOR4, -NHSO2R4, -N (R4) 2, R3 represents a hydrogen atom, a (C1-C4) alkyl group, - (CH2) 7OH, - (CH2) pNH2, - (CH2) n COOH, - (CH2) nCOOR4, -CH2) nCN, - (CH2) n-tetrazolyl, - (CH2) nCONH2, - (CH2) nCONHOH, - (CH2) pSH, - (CH2) nSO3H, - (CH2) nSO2NH2, - (CH2) nSO2NHR4, - (CH2) nSO2NR4R5, - (CH2) nCONHR4, - (CH2) pNHSO2R4, - (CH2) pNHCOR4, - (CH2) pOCOR R4 and R5 are each a (C1-C4) alkyl group, n = 1 to 4,P = 2-4 and a represent a benzo group that may or may not be replaced for the treatment and production of an effective drug to treat and prevent various forms of diseases, such as heart disease, kidney disease, eye disease, encephalopathy or ischemia and heart failure of lower members, Myocardial infarction, elangor, thrombus (alone or related to thrombus)Arteritis, intermittent claudication, the recovery disorder after angioplasty, and various diseases related to osteoporosis, microcirculation system disorder or pulmonary dysfunction. It can also be used to treat and prevent hypertension, vein, lung, portal, kidney or eyeball, and coronary or peripheral vascular infection.