- 6 and 7 - amino acids - tetrahidroisoquinolinacarboxilicos replaced, Process for their preparation, their use in the preparation of a,Medicine containing them and Process for its preparation

摘要

6-and 7-amine-tetrahydroisoquincalarboxyl substitutions, including (I) and (or) La formula (I) compounds in stereoisomerized form and (or) a physiologically compatible formula (I) salt, in which ntando: R1 es: 1 is represented. Phenyl, 2. 1. Phenyl, replace once or twice with the following materials: 2.1 C1-6 tar, linear, cyclic or branched, 2.2-oh, 2.3 c1-6-c (or) - O -,2.4 C1-6-O--2.5.c1-4-o-tar-1-62.6 halide, 2.7-cf3, 2.8-cn, 2.9-no2, 2.10 ho-c (o) -,2.11 c1-6-o-c (o) tar,2.12 methylenedioxy, 2.13 R5 - (R6) N-C (o) -,R5 y R6 is equal or different, representing a C1-6 or 2.14 R5 - (R6) n -.1. R5 yr6 is equal to or different from C1-6 hydrogen atom or tar; The heteroaromatic radical substances ingested in the following 3.1 to 3.15 groups, as described in 2.1 to 2.14, were not substituted: 3.1 pirol, 3.2 pyrazol, 3.3 pyrazol, 3.4 triazol, 3.5 thiophosphor, 3.6 thiazole, 3.7 oxazol, 3.8 isoxazol, 3.9 pyridine, 3.10 pyridine, 3.11 indol, 3.12 benzotiz, offensidal, 13, 3.14 benzoxazol or 3.15 benzotiazol; 4. -Oh, I mean, a girl. -O-r14 means covalent bond - CH = ch-o-c: c-y, wherein R14 means (1) C1-6, 2) cyclo-c3-6, 3) benzene or (4) phenyl;Six -COOH means a covalent link - CH = ch O-C:: C -;Seven 1-6, 8 C3-6-o-tar C1-4; 9 Hydrogen halide with covalent linkage, ch = ch-o-c:: C--10. -CN and A denoting a covalent bond, -CH = CH- or C ::: C-;Eleven -No 2 and meaning a circoeconovalente-Ch=CH-O C:-CF3, representing r2:1 That's what I want to say. That's it.R7 means 2.1 hydrogen atom, 2.2 C1-6 tar,