Use of a Taxane derivative for the preparation of a Pharmaceutical composition.Use of a biodicponibilidad Improver of the derivative set afrmaceutico oral dosage form and understands it, and Method for forming an active Agent bioavailable.

摘要

The use of a taxonomic derivative to prepare a useful pharmaceutical ingredient for a therapeutic method, including oral presentation to a human patient with a disease related to the derivative Therefore, the derivative was effectively removed to treat the disease. The derivatives of taxano are Paclitaxel; docetaxel;A notorious derivative similar to plactitaxel or doeaxel and a prediction derivative called esplaclitaxel-2-mpm or docetaxel-2-mpm. The effective dose of placliftaxel is about 2-30 mg / kg of basic weight or 20-1000 mg / m2 of patient's body area. In addition, the aim of this method is to make steroid derivatives orally available to human patients in sufficient quantities to treat diseases associated with such derivatives.This includes the combination of oral administration of patients, the number of classified animals for effective treatment, plus the effective amount of biocompatible enhancers selected from the CYCLOPROPYLENE glycol to Z (me-ile-4) - CYCLOPROPYLENE, dihydrocyclopropane and propylene ceclosporina a groups. Based on the patient's Alpine ratio, the dosage of enhancer is between 0.1 and 20 mg / kg. The administration of this enhancer is as follows: (a) the prediction time is about 0.5-72 hours; and (b) the time of death is less than 0.5 hours.At the same time, or within the next 0.5 hours; or (c) two, about 0.5-72 hours in advance, plus less than 0.5 hormone, to be managed by the tax bureau. And enhancers are managed in an independent dose form