Pharmaceutical composition and method for the treatment of diseases associated with the abnormal proliferation of active T lymphocytes

摘要

The present invention relates to a pharmaceutical composition comprising a suitable pharmaceutical excipient and an inhibitor directed against an antigenic structure defined by the following characteristics: the antigenic structure is expressed by APC (Antigen Presenting Cells) cells, by Daudi and Namalwa lymphoblastoid lines and some promyelocytic lines, particularly HL60 and K562 cells, the antigenic structure is expressed by peripheral blood monocytes (CD14+) following a lipopolysaccharide (LPS) treatment, the antigenic structure is expressed by T lymphocytes (CD3+) in response to treatments with various agents such as PHA or PMA, alone or in combination with a calcium ionophore, the antigenic structure is expressed by the cell sub-populations expressing the specific B lymphocyte CD20 marker, the antigenic structure is also expressed by dendritic cells, the antigenic structure is essentially protein in nature, and is protease-degradable, particularly with papain and proteinase K, and is partially degradable by an inhibitor...IMAGE