Promoter region of bmp-4 and its fragments, vector comprising a promoter region of bmp-4 or its fragments, host cell, process for the identification of therapeutic agents for the prevention and / or treatment of osteoporosis, and use of ici 164384.

摘要

"BMP-4 PROMOTING REGION AND ITS FRAGMENTS VECTOR UNDERSTANDING A BMP-4 PROMOTING REGION OR ITS FRAGMENTS, HOST CELL, PROCESS FOR THE IDENTIFICATION OF THERAPEUTIC AGENTS FOR THE PREVENTION AND / OR TREATMENT OF OSTE4, 164 . The present invention relates to a promoter region of human bone morphogenetic protein (BMP-4), and fragments thereof, to a vector comprising said promoter region, and host cells comprising said promoter regions or vectors. The invention also concerns a process for the identification of therapeutic agents for use in the prevention and / or treatment of osteoporosis, in which said process comprises the steps of: a) introducing into a cell a first expression vector comprising a BMP promoter region -4 or fragments thereof operably linked to a reporter gene, and a second expression vector comprising DNA encoding the estrogen receptor; b) making contact of said cell with potential therapeutic agents; c) monitor the expression of the protein encoded by the reported gene.