5-aryl-3- (8-azabicyclo 3.2.1 oct-3-yl) -1,3,4-oxadiazole-2 (3h) -one derivatives as 5-ht4 receptor ligands

摘要

Invention Patent: B "DERIVATIVES OF 5-ARYL-3- (8-AZABICYCLE [3.2.1] 0CT-3-IL) -1,3,4-OXADIAZOL-2 (3H) - ONA AS RECEIVERS BINDERS 5-HT ~ 4 ~ "D. The invention relates to a compound of general formula (I) in which R ~ 1 ~ represents an alkyl or cycloalkylmethyl group, X ~ 1 ~ represents a hydrogen atom or a halogen atom or an alkoxy group or OR ~ 1 ~ and X ~ 1 ~ together represents a group -OCH ~ 2 ~ O-, -O (CH ~ 2 ~) ~ 2 ~ -, -O (CH ~ 2 ~) ~ 3 ~ -, -O (CH ~ 2 ~) ~ 2 ~ O- or O (CH ~ 2 ~) ~ 3 ~ O-, X ~ 2 ~ represents a hydrogen atom or halogen atom, and R ~ 2 ~ represents either a hydrogen atom, or a optionally substituted alkyl group, or optionally substituted phenylalkyl group, or a - (CH ~ 2 ~) ~ n ~ CO-Z group where n represents a number from 1 to 6 and Z represents a piperidin-1-yl group. The invention is applicable in therapy.