Analogs of triterpene saponin endowed with adjuvant and immunostimulatory activity

摘要

"TRITERPENE ANALOGUES SAPONIN WITH ADJUVANT AND IMMUNOSESTIMULATORY ACTIVITY" The present invention is directed to new chemical compounds in which the lipophilic portion such as a lipid, fatty acid, polyethylene glycol or terpene is covalently linked to a de-acylated or acylated saponin triterpene means of the carboxyl group present in the 3-O-glucuronic acid of the triterpene saponin. The binding of the lipophilic portion to saponin 3-O-glucuronic acid such as Quillaja deailosilosonon, lucioside P, or saponin from Gypsophyla, Saponaria and Acanthophyllum increases its adjuvant effects on cell-mediated and humoral immunity. In addition, binding to the lipophilic moiety to the residue of non-or de-acylapapine 3-O-glucuronic acid produces a saponin analogue that is easier to purify, less toxic, chemically more stable, and has equal or better adjuvant properties than than the original saponin.