Histamine or serotonin binding compound, protein, therapeutic or diagnostic composition, vaccine, use of histamine or serotonin binding protein or protein, nucleic acid molecule, expression or cloning vector, host cell, and transgenic animal .

摘要

'' HISTAMINE OR SEROTONIN BINDING COMPOUND, PROTEIN, THERAPEUTIC OR DIAGNOSTIC COMPOSITION, VACCINE, USE OF HISTAMINE OR SEROTONIN BINDING COMPOUND, NUCLEIC ACID MOLECULE, EXPRESSION, EULE, EXPRESSION, EXPRESSION VENT, TRANSGENIC ANIMAL '' The present invention relates to serotonin and histamine binding molecules that have a binding site with the precise molecular configuration that is necessary to give the molecule a high affinity for histamine. The invention includes proteins, peptides and chemical compounds that have this molecular configuration and are thus capable of binding to histamine with high affinity. These molecules can be used to regulate the action of histamine or serotonin, in the detection and quantification of histamine or serotonin and in the treatment of various diseases and allergies. The molecules can also be used as components of vaccines directed against blood-sucking ectoparasites.