Copolìmero styrene and divinylbenzene functionalised with a high degree of amino groups metìlicos EPM (- 1) and its use as a new type of resin aniÈnica swing

摘要

"Copolu00ecmero styrene and divinylbenzene functionalised with a high degree of amino groups metu00eclicos b (1 - 1) d and its use as a new type of resin resins containing mat aniu00c8nica swingRizes apolar styrene divinylbenzene type can take solvatu00e1veis in aqueous medium, depending on the amount of sheets based positive incorporated into its structure.Tests with a resin containing sheets aminometilicos and called amino methyl resin, containing 4.9 mmol / g of content amu00ednico, here called the EPM - 1,Showed that she solvata right in the middle of polar organic solvent and water.Based on a special strategy developed to estimate pKa of ionisable groups of resins was found value around 5.5 for the pKa of the amino group of the resin.As the model compound to the anion chromatographic tests with EPM - 1 peptide fragments with different loads have been synthesized and tested negative in purification on a column.Demonstrating that this polymer can be considered as an alternative of resin and anion type swing your job can be extended for the purification of other types of compounds with loads of negActive.In addition, by having amino groups, primary easily derivu00e1veis in its structure.This resin can also become the precursor of other resins with different chromatographic potentialities.The same can be the case for change, for example, the degree of interbreeding of the copolymer of divinylbenzene, inducing changes in its characteristics of solvatau00e7u00e3o, porosity, etc.Therefore, the nature of affecting its use as polymeric matrix.