首页> 外国专利> Galenic form of immediate release and prolonged release administered orally comprising an absorption stimulating agent and use of this absorption stimulating agent

Galenic form of immediate release and prolonged release administered orally comprising an absorption stimulating agent and use of this absorption stimulating agent

机译:口服吸收的盖伦制剂即刻释放和延长释放,包含吸收刺激剂和该吸收刺激剂的用途

摘要

Invention Patent: B "IMMEDIATE RELEASE AND PROLONGED RELEASE GALLERY ORAL ADMINISTRATIVE UNDERSTANDING AN ABSORPTION AND USE OF THIS ABSORPTION STIMULATING AGENT" D. The present invention relates to a galenic form that can be administered orally, allowing enhanced absorption by the transmembrane or paracellular root in the gastrointestinal tract of active ingredients which are hydrophilic or ionizable in a physiological medium, comprising at least one of the active ingredients, a stimulating agent of absorption having an HLB greater than 8, the absorption stimulating agent referred to consists of one or more lipid substances chosen from: polysorbates; polyoxyethylene and alkyl ethers; polyoxyethylene esters and fatty acids; fatty acids; fatty alcohols; bile acids and salts thereof with pharmaceutically acceptable cations; C ~ 1 ~ C ~ 6 ~ alkanol esters with fatty acids, polyol esters with fatty acids, said polyol comprising from 2 to 6 hydroxyl functional groups; and polyglycolated glycerides; in combination with one or more pharmaceutically acceptable excipients, dosage forms comprising captropyl are excluded.
机译:发明专利:“立即释放和长时间释放的画廊口服吸收性药物,理解和使用该吸收刺激剂” 。本发明涉及一种盖仑形式,其可以口服施用,从而允许在生理介质中亲水或可离子化的活性成分在胃肠道中被跨膜或细胞旁根增强吸收,所述活性成分包含至少一种活性成分, HLB大于8的吸收性刺激剂,该吸收性刺激剂由一种或多种选自以下的脂质物质组成:聚山梨酸酯;聚氧乙烯和烷基醚;聚氧乙烯酯和脂肪酸;脂肪酸;脂肪醇胆汁酸及其与药学上可接受的阳离子的盐; C〜1〜C〜6〜链烷醇与脂肪酸的酯,多元醇与脂肪酸的酯,所述多元醇包含2至6个羟基官能团;和聚乙醇酸甘油酯;与一种或多种药学上可接受的赋形剂组合,排除了包含己内酯的剂型。

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