Pyridines and piperidines Compounds, their Salts and solvates, Nociceptin receptor inhibitors and their pharmaceutical compositions, and their use for the treatment of Cough, Asthma, anxiety,Depression and Alcohol Abuse.

摘要

New Compounds of formula, or a Salt or pharmaceutically acceptable solvate thereof, in which the dotted line represents a Double Link X1 is alkyl, Optional;Heteroaqrilo cycloalkyl, optionally substituted aryl, or haterocicloalquilo; x2 is Cho.CN, amino,Optionally substituted alkyl or aryl or Heterocyclic benzofusionado; x1 and x2 is optionally substituted Hydrogen; x1 or x2 together form a Heterocyclic Spiro Option GroupAt present, benzofusionado.R1, R2, and R4 RT3 are independently H or alkyl, or (R1 and R4) or (R2 and R3) or (R1 and R3) or (R2 and R4) together can form a Bridge alquileno 1 to 3 carbon aromos.Z1 is alkyl, aryl, heteroaryl, or optionally substituted cycloalkyl heterocicloalquilo or CN; Z1 or Z2 is h; Z3 is H or alkyl or Z1,.Z2 and Z3 together with Coal to form bicyclic Rings which are saturated or unsaturated; Pharmaceutical compositions including the same, and the use of such compounds asNociceptin receptor inhibitors useful for the treatment, anxiety, Cough, Asthma, depression and Alcohol Abuse.