Process for the stereoselective microbial reduction of 4 - (3,4-dichlorophenyl) - dihydro - 1 (2H) - naftalenona racmica in a mixture of CIS and trans tetraloles,Comprising contacting the compound with a micro organism or Enzyme System Reduction, incubate the mixture, and recovering the enantiomer (S) of the compound.

摘要

Procedure to carry out microbial stereoselective reduction of a Racemic tetralona: which comprises contacting a compound with a microorganism or a reduction system andNzimatica capable of carrying out this Reduction, which comprises an enzyme derived from this organism and a cofactor for the Enzyme.And incubate the mixture under conditions sufficient to produce the tetralol formula and let tetralona REACT substantially without the formula or tetralona Chiral.The Chiral tetralona can be used in the synthesis of sertraline. This procedure also optionally includes the separation of tetralona formula tetralol formula.The tetralol can be recycled to produce the compound of formula I and this procedure is repeated to produce more tetralona desired Formula V.