Derivatives of N - (heteroaryl condensate condensate or heterocycle - 4 - (n, N - dimetilcarbamoiloxi) - phenyl alanine, composicionfarmeceutica,Useful as an inhibitor of leukocyte adhesion mediated by vla-4 inflamatoriascomo to treat diseases, Asthma, diabetes, atherosclerosis, arthritis, Alzheimer's disease, tissue transplantation.

摘要

Compounds are described that set the vla-4, formula la and LB wherein a, R1, R2, R3, W, Q and x are described in claim 1.Some of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by vla-4.Such compounds are useful in the treatment of inflammatory diseases in a Mammalian patient, for example in a person such as Asthma, Alzheimer's disease, arterosclorosis,Dementia caused by AIDS, diabetes, irritable bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and ischemia in the myocardium.The compounds can also be administered for the treatment of inflammatory diseases of the Brain, such as multiple sclerosis.