POLYPEPTIDES, DERIVED FROM ENDONEXIN 2, HAVING HEPATITIS B VIRUS RECEPTOR ACTIVITY AND THEIR USE IN DIAGNOSTIC AND PHARMACEUTICAL COMPOSITIONS.

摘要

The invention relates to a mammalian nonhuman transgenic animal liable to be infected by HBV and moreover liable to suffer from hepatocellular damage, caused by the constitutive or inducible expression of the human endonexin II gene or by the nucleotide sequence coding for its muteins or fragments, the said gene or the said nucleotide sequence being introduced into such a transgenic animal as a model for testing potential drugs.