PROCESS FOR INHIBITING THE AGGREGATION OF RECOMBINANT PORCINE SOMATOTROPIN

摘要

According to the present invention, at least one of the four cysteine residues in recombinant pork hair trypsin is replaced, modified, deleted or derivatized. Preferably, the replacement of cysteine residues is arginine, lysine, aspartic acid, glutamic acid, asparagine, glutamine, histidine, alanine, glycine, isoleucine, leucine, valine, phenylalanine, tryptophan, residues of tyrosine, methylene, serine, threonine or proline are used. Modification of the acysteine residue on the salt will preferably convert the residue to cysteic acid. ŕ