Tetrahydroisoquinolinylmethylazabicyclo[3.2.1]octane derivatives of formula (I), their salts and optical isomers are new. R1- R3 = H, halo, OH, 1-4C alkyl or 1-4C alkoxy; R4 = H, halo, 1-4C alkyl, 2-methoxyethoxy, 1-6C alkoxy, 3-6C cycloalkylmethoxy or phenylmethoxy; or R3+R4 = methylenedioxy; Z = O or (H,H); R = ethoxy (when Z is O) or phenyl (optionally substituted by one or more halo, 1-4C alkyl, 1-4C alkoxy or amino).
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机译：式（I）的四氢异喹啉基甲基氮杂双环[3.2.1]辛烷衍生物，其盐和光学异构体是新的。 R 1 -R 3 ＝ H，卤素，OH，1-4C烷基或1-4C烷氧基; R4 = H，卤素，1-4C烷基，2-甲氧基乙氧基，1-6C烷氧基，3-6C环烷基甲氧基或苯基甲氧基;或R3 + R4 =亚甲二氧基; Z = O或（H，H）; R ＝乙氧基（当Z为O时）或苯基（任选地被一个或多个卤素，1-4C烷基，1-4C烷氧基或氨基取代）。
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