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Sustained release liquid aqueous ophthalmic delivery system and liquid aqueous ophthalmic pharmaceutical composition both containing the polymer chitosan
Sustained release liquid aqueous ophthalmic delivery system and liquid aqueous ophthalmic pharmaceutical composition both containing the polymer chitosan
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机译:均含有聚合物壳聚糖的缓释液体眼用水性药物递送系统和液体眼用水性药物组合物
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摘要
Disclosed is a sustained release liquid aqueous ophthalmic delivery system and a method of providing a slow and sustained release of ophthalmic treating agents to the eye of a mammal which comprises administering to the eye of a said mammal an effective amount of a homogeneous liquid aqueous ophthalmic pharmaceutical composition, of pH between about 3.0 and about 6.2, which is adminstrable in drop form and which comprises an ophthalmically effective concentration of a said ophthalmic treating agent and about 0.05% to about 10% by weight of the polymer chitosan; said polymer consisting essentially of (A) monomeric beta (1-4)-D-glucosamine linked units and of (B) monomeric beta (1-4)-D-glucosamine linked units which are scattered randomly in the molecule of the polymer, the numerical proportions of A and B being from about 60 to about 99% of A and about 1 to about 40% of B, the viscosity rating being from about 3 to about 3000 cps; in which method, upon contact with the higher pH of the ocular fluid, said liquid formulation is converted to a stiff gel from which the ophthalmic treating agent is slowly released over a prolonged period of time.
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