3-SUBSTITUTED OXINDOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR OPENING OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS, COMPRISING THEM

摘要

Compounds of the formula wherein R is hydrogen, hydroxy of fluoro; R1, R2, R3 and R4 each are independently hydrogen, C1-4 alkyl, halogen, trifluoromethyl, phenyl, p-methylphenyl or p-trifluoromethylphenyl; or R1 and R2, R2 and R3 or R3 and R4 are joined together to form a benzo fused ring; R5 is hydrogen or C1-4 alkyl; and R6 is chlorine or trifluoromethyl; or a nontoxic pharmaceutically acceptable salt, solvate or hydrate thereof. 509 כ" ג בתמוז התש" ס - July 26, 2000