Use of a neuroactive peptide having at least one of the biological activities of angiotensin IV or a biologically active analogue

摘要

The use of a neuroactive peptides or analogues thereof, having at least one of the biological activities of angiotensin IV, in the manufacture of a pharmaceutical composition for modulating neuronal activity. The peptide comprises the sequence Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe and the biological activities demonstrated by the peptide are selected from the group consisting of modifying learning, modifying behaviour, vasoactive effects, dilation of cerebral arteries, renal blood flow, increase in stereotype behaviour, facilitating memory retrieval, neurite modelling and alleviation of the effects of spinal cord injury. Also disclosed is a method of screening for putative agonists or antagonists of the effect of LVV-haemorphin-7 on neuronal activity.