Use of benzothiophene (raloxifene) derivatives in treatment of osteoporosis, lowering serum cholesterol levels and inhibiting estrogen dependent cancer

摘要

This use of benzothiophenes of the formula I ; where R1 is H, OH, alkoxy, OC(O)alkyl, OC(O)Oalkyl, OC(O)phenyl, OC(O)Ophenyl or SO2alkyl, R2 is R1, Cl or F, R3 and R4 each are alkyl or combine to form a morpholine or a 5-8 membered nitrogen containing hetero ring and X is CH2, CHOH, O or CO; is for inhibiting osteoporosis, lowering serum cholesterol levels and inhibiting estrogen-dependent cancer.