C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ice/ced-3 family of cysteine proteases and for treatments of inflammatory, autoimmune, neurodegenerative disorders and in the prevention of ischemic injury

摘要

The application is directed to (N-substituted)indole ICE/ced-3-inhibitor compounds of the formula I where n is 1 or 2; R1 is alkyl, cycloalkyl, optionally substituted phenyl, phenylalkyl, heteroaryl and (CH2)mCO2R; R2 is R1, H or Cl; R3 is H, alkyl, cycloalkyl, phenylalkyl, or substituted phenyl alkyl, and X and Y each are H, halo, trihalomethyl, amino, substituted amino, carboxy, hydroxy, alkoxy, alkylthio, optionally substituted alkyl, optionally substituted cycloalkyl, and optionally substituted phenyl. Also included are pharmaceutical compositions of such indole compounds, and the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.