Triazolo pyridazine hydrochloride derivatives as LIGANDS FOR Receptors, Gaba

摘要

Refers to a compound 7 - (1,1-dimethylethyl) - 6 - (2 - ethyl - 2H - 1,2,4 - triazole - 3 - ilmetoxi) - 3 - (2-fluorophenyl) - - 1,2,4 triazolo [4,3-b] pyridazine hydrochloride, polymorphic.It also relates to a method for preparing comprising reacting chlorine - 6 - 7 - (1,1-dimethylethyl) - 3 - (2-fluorophenyl) - - 1,2,4 triazolo [4,3-b] pyridazine hydrochloride in 1 - methyl - 2 - pirrolidinona,In the presence of Sodium hydroxide at a temperature of zero. Also refers to 7 - cyclobutyl - 3 - (2,6 - difluorofenil) - 6 - (2 - methyl - 2 - 1,2,4 - triazole 3 - - - - ilmetoxi) 1,2,4 triazolo [4,3-b] pyridazine hydrochloride.The Compound is a gaba receptor agonist may therefore be useful for the Treatment or prevention of anxiety