PHARMACEUTICAL PRODUCTS FOR CURING AND PREVENTING DISEASES RESULTING FROM THE DAMAGING OF THE VASCULAR ENDOTHELIAL CELLS

摘要

The present invention relates to the use of certain hydroxylamine derivatives in the therapy or prevention of illnesses connected with the dysfunction of the vascular endothelial cells. Another object of the invention is the use of the same compounds in the preparation of pharmaceutical compositions against the above diseases. In the general formulae I and II, Re1 and Re2 independently refer to a hydrogen atom or a straight or branched alkyl group of 1 to 6 carbon atoms, or Re1 and Re2 together with the nitrogen atom in-between form a saturated 5 - 7 membered heterocyclic group, containing optionally further nitrogen and/or oxygen heteroatoms, A refers to a straight or branched alkyl group of 4 to 12 carbon atoms, a phenyl group, substituted or unsubstituted, containing preferably an alkyl-, haloalkyl- or nitro group as substituent, or a 5 - 6 membered heteroaromatic ring containing nitrogen, oxygen or sulfur, in the general formula I, Z refers to a covalent bond, and in the general formula II to a covalent bond or =NH group, in the general formula I, X refers to a halogen atom or to a - NRe3Re4 group, wherein Re3 and Re4 independently refer to a hydrogen atom or a straight or branched alkyl group of 1 to 6 carbon atoms, while in the general formula II X refers to an oxygen atom, in the general formula II, R' refers to a hydrogen atom or a straight or branched alkyl group of 1 to 6 carbon atoms, and in the general formulae I and II, Y refers to a hydrogen atom, a hydroxyl group or an acyloxy group, which contains preferably the acyl part of a long chain fatty acid of 8 to 22 carbon atoms, or of a cyclic aromatic carboxylic acid as its acyl component, and in the compounds of the general formula I wherein X refers to a - NRe3Re4 group and Y refers to a hydroxyl group, the X group is condensed with the Y substituent and forms the intramolecular ring represented by the general formula III, in which formula A, Z, Re1 and Re2 have the same reference as indicated above.