TETRALINS THAT HAVE A PHENYL SUBSTITUTE ON THE AROMATIC RING AND ITS USE IN THE TREATMENT OF EPILEPSY, APOPLEJIA AND BRAIN OR SPINAL TRAUMA.

摘要

DISCOVERED COMPOUNDS OF FORMULA (I) IN WHICH R SUB, 1} AND R SUB, 2}, INDEPENDENTLY, ARE HYDROGEN, ALKYL (C SUB, 14}), ALCOXY (C SUB, 1-4}), ALKYLTIO (C SUB, 1-4}), HALOGEN, TRIFLUOROMETHYL, TRIFLUOROMETOXY, CYAN, ALCANOYL (C SUB, 2-5}), ALKYL (C SUB, 1-4}) SULPHONYL OR SULPHAMOIL; R SUB, 3} ES HYDROGEN, HYDROXY, ALKYL (C SUB, 1-4}), ALCOXI (C SUB, 1-4}), HALOGEN, CIANO, ALCANOYL (C SUB, 2-5}), CARBAMOIL, ALKYL (C SUB, 14}) SULFONILOXI OR TRIFLUOROMETILSULFONILOXI; YR SUB, 4} YR SUB, 5}, INDEPENDENTLY, ARE HYDROGEN, ALKYL (C SUB, 1-4}), HYDROXYALKYL (C SUB, 2-4}) OR PHENYLALKYL (C SUB, 1-4}), OR TOGETHER WITH THE NITROGEN ATOM WITH WHICH A PYRROLIDINYL, PIPERIDINE OR PIPERAZINYL GROUP IS UNITED, IN THE FORM OF FREE BASE OR SALT OF ADDITION OF ACID. COMPOUNDS IN ACCORDANCE WITH FORMULA (I) ARE USEFUL IN THE TREATMENT OF EPILEPSY, APOPLEJIA, AND BRAIN OR MEDULAR INJURIES.